RAF Typhoon FGR4s have operated alongside French aircraft in a combined operation against an underground arms cache in Syria employed by the Daesh militant organization, per a report from the British defence ministry.
The location, pinpointed through reconnaissance, was believed to be storing arms and explosives, the release indicated, and was located in mountainous terrain just north of Palmyra in the heart of Syria.
"The RAF jets employed Paveway IV guided bombs to hit a number of approach shafts providing entry to the site... initial indications are that the strike was effective," the MoD said.
There was no indication of any harm to civilians in the strike late on Saturday and all the aircraft returned to base without incident, the ministry further stated.
The British jets were backed up by a Voyager aerial refuelling aircraft.
The Islamic State group - referred to as Daesh - enforced jihadist rule over parts of Syria and Iraq until 2019.
"This action demonstrates the UK's leading role, and resolve to operate in unison with allied nations, to stamp out any resurgence of IS and their dangerous and violent ideologies in the area," Britain's Defence Chief the minister stated.
British military aircraft have carried out patrols over Syria to "deter any efforts to regroup" of IS subsequent to its military defeat at the Baghuz confrontation in 2019, the ministry said.
"I want to thank the personnel of the UK armed forces who took part in this strike for their expertise and their courage," Healey said. "They were among a great many British personnel on duty over the festive period. This mission, to take out terrorist threats who pose a risk to our way of life, demonstrates how UK forces are always on standby, continuously, protecting the UK within its borders and powerful internationally."
During December, the American forces conducted what it termed a "massive strike" targeting Daesh sites in Syria, after an assault resulted in the deaths of two American soldiers and a civilian linguist in Palmyra.
The UN estimates Islamic State still maintains an estimated 5,000 to 7,000 militants in both countries.